How to Use Sildenafil for Best Results

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Written By Julie Ingram
how to use sildenafil for best results

Sildenafil, known by its brand name Viagra, is a medication that treats Erectile Dysfunction (ED) in men or Assigned Males at Birth (AMAB). 

Erectile Dysfunction is an inability of men to get or maintain a firm erection.

Sildenafil (Viagra) works by dilating the penile blood vessels, increasing blood flow to the penis.

This improves erectile functions in men with ED.

But Sildenafil works best when used in the right way. From dosage timing to food, all can influence its effectiveness. 

This article will explore the best practices for how to use Sildenafil for best results. 

How to use Sildenafil for best results

Sildenafil is an effective treatment for ED, but taking the medication correctly is crucial.

Dosage, timing, food, sexual stimulation, storage, etc., can affect Sildenafil’s effectiveness.

Understanding and using these factors to your advantage can help you to get the most benefits of this medicine. 

Appropriate Sildenafil dosage

FDA has approved three doses of Sildenafil, i.e., 25mg, 50mg, and 100mg.

These Sildenafil (Viagra) dosages differ from person to person. The doctor can determine the appropriate dosage depending on your medical needs. 

Doctors usually prescribe a 50mg dose of Sildenafil. This can be increased to 100mg or decreased to 25mg based on your response to the medication. 

Only the doctor can adjust the doses if you are not responding to a 50mg dose. 

It is necessary not to take more than the recommended dose of Sildenafil. 

Some people think taking more than the recommended dose will improve their condition faster.

But this is not the case. If your body doesn’t require a higher Sildenafil dose, it may lead to dose-related side effects.

Therefore, it is important to contact a doctor and adhere to their suggestions.

Timing is Key

It is essential to plan your Sildenafil dosage ahead of sexual time.

This is because Sildenafil takes around 30 to 60 minutes to start working. Your body needs time to absorb and process the medication after ingestion. 

Once you swallow the pill, it’s absorbed into your bloodstream. After about 60 minutes, it reaches its peak concentration in the bloodstream and has maximum effect on your body. 

This onset time of Sildenafil can vary from person to person. It depends on the individual’s health and medical conditions. 

That is why it is important not to rush into sexual activity immediately after taking the medication.

You must wait for 30 minutes before expecting it to be effective. But it is best to wait up to 60 minutes for it to reach its full potential.

Eager to know the duration of action of Sildenafil? Dive into this articleThe Time factor: How Long Does Sildenafil Last

As per NIH, in some cases, Sildenafil showed effects within 12 minutes of ingestion. But that was a small study and cannot be used to represent the whole population.

Be Sexually Stimulated

Sildenafil does not produce an erection on its own.

Instead, it enhances the effects of Nitric Oxide (NO), which is released during sexual arousal. 

NO helps in the production of cyclic Guanosine Monophosphate (cGMP). 

cGMP is a molecule that helps dilate the penile blood vessels. This dilation allows for increased blood flow to the penis, which is necessary for a firm erection.

But PDE5 enzymes are present in the penis, which are responsible for breaking down cGMP levels.

Sildenafil works by blocking the actions of PDE5 enzymes. 

This allows for restoring cGMP levels, which increases blood flow to the penis. Thus, helping men to get or maintain a firm erection.

Even though Sildenafil is an effective treatment for ED, it requires sexual stimulation to work. 

So, indulge yourself in a lot of foreplay to get sexually stimulated.

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  • Don’t take more than one pill in 24 hours

    It is not advisable to take more than one Sildenafil dose in 24 hours because it can increase the risk of side effects. 

    One of the potential side effects of Sildenafil is a drop in blood pressure. This can be dangerous or life-threatening if it falls too low. 

    This can also make you vulnerable to other side effects of Sildenafil. These include headaches, dizziness, nausea, nasal congestion, etc. 

    So, it is crucial to stick to one dose in 24 hours to reduce the likelihood of unwanted effects.

    Be aware of its interactions

    It is crucial to be aware of Sildenafil’s interactions because certain medications or conditions can interact with it.

    This can alter its effectiveness or even cause adverse reactions. 

    Some of the common interactions of Sildenafil include:

    • Medicine containing Nitrates
    • Alpha-blockers medicines 
    • Other ED medicines like Tadalafil and Vardenafil
    • Liver or kidney impairment 
    • Condition of Hypotension 
    • Interaction with alcohol and grapefruit juice 

    These interactions can range from mild to severe or can be life-threatening in some cases. 

    Knowing the potential interactions of Sildenafil allows you to make the best use of it. 

    Also, you must inform your doctor about any medications you are taking. This helps to avoid any potential interactions.

    Watch for side effects

    viagra headacheSource: pixabay

    Sildenafil is a safe and well-tolerated medicine. But, like all medications, it has the potential to cause side effects. 

    Therefore, knowing its adverse effects is essential to minimize the risk of experiencing them.

    Some common side effects of Sildenafil include

    • Headaches
    • Dizziness
    • Nasal congestion
    • Back pain
    • Indigestion
    • Flushing
    • Muscle pain
    • Allergic reactions 

    These adverse effects are temporary and need minimal to no medical attention. They disappear once your body adjusts to your dosage.

    If any of these side effects cause you to worry, consult a doctor. He/she may be able to adjust your dosage or recommend alternatives to Sildenafil

    Store Sildenafil Properly

    Proper storage of Sildenafil is crucial to maintain its effectiveness and safety. 

    This can help to keep the medicine intact. Thus, allowing you to make the best use of it.

    The ideal storage conditions for Sildenafil include the following:

    • Keep it in a dry and cool place.
    • Store it at room temperature, between 20°C and 25°C.
    • Do not expose it to direct sunlight or moisture. 

    Also, store Sildenafil out of reach of children and pets to prevent accidental ingestion.

    Keep the medicine intact in its original packaging with the expiration date clearly visible. This is to ensure that you do not accidentally use an expired medication. The FDA does not recommend using medicines past their expiration dates.


    In summary, Sildenafil is a safe and effective medication for treating ED in men. 

    To make the best use of Sildenafil, it is important to follow these six tips:

    • Consult a doctor to determine the appropriate Sildenafil dosage for you
    • Take Sildenafil on an empty stomach
    • Get in “that mood” to make Sildenafil work
    • Do not take more than one dose in 24 hours
    • Ask the doctor about the interactions and side effects of Sildenafil
    • Store Sildenafil properly.

    The above guidelines will help men with ED to make the best use of Sildenafil.

    Frequently Asked Questions

    Can I split a Sildenafil tablet to adjust my dose?

    Sildenafil is a film-coated and unscored tablet. It is generally not recommended to split these types of pills. As per, splitting film-coated tablets is not safe. 
    Moreover, unscored tablets do not have a visible line in the middle, meaning they are not suitable for splitting.

    Can I use Sildenafil with grapefruit juice?

    No, it is not advisable to use Sildenafil with grapefruit juice. This is because grapefruit juice contains compounds that can interfere with the breakdown of Sildenafil. 
    This can result in higher levels of the medication in the body. Thus, increasing the risk of its side effects and interactions.

    Can I take Sildenafil with other medications?

    Sildenafil can be taken with medications that do not have an interaction with it. Certain medications, like Nitrates, Alpha-blockers, other ED medicines, etc., interact with Sildenafil. 
    So, it is advisable not to take Sildenafil with these medicines. It is essential to inform your doctor about the medicines you are taking.

    What is the recommended dosage of Sildenafil?

    The recommended starting dosage of Sildenafil is 50mg. It is taken 30-60 minutes before sexual activity. 
    However, your doctor may adjust your dosage based on your individual needs and health status. Do not exceed the prescribed dosage without consulting your doctor.

    How long do the effects of Sildenafil last?

    The effects of Sildenafil usually last for 4-6 hours. However, the duration may vary depending on individual factors such as age, health, and dosage. 
    It is necessary to wait 24 hours before taking another dose of Sildenafil.

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