Sildenafil is a medication that is primarily used to treat Erectile Dysfunction (ED).
Due to its vasodilating properties, the FDA has also approved it to treat Pulmonary Arterial Hypertension (PAH).
Sildenafil works by relaxing the blood vessels in the body.
This increases the flow of blood to the penis and pulmonary arteries. Thus, improving erections and reducing blood pressure in the arteries.
There are many questions and doubts about Sildenafil. One such question is how long does Sildenafil last.
Understanding the duration of Sildenafil’s effects is important for safe and effective use.
This article will provide information on the duration of the effects of Sildenafil. It will also explore the factors affecting the longevity of Sildenafil’s effects.
How long does Sildenafil last in the body
The effects of Sildenafil can last up to 4 hours in the body.
But the strength of these effects varies depending on the individual’s health and the dose taken.
In some cases, the effects of Sildenafil can last up to 12 hours in men with ED. But, the medication’s effects generally weaken over time.
For example- the effects at 2 hours are stronger than those at 4 hours after taking Sildenafil.
To get the most out of the medication, it’s best to consume it 1 hour before any sexual activity.
This is because the concentration of Sildenafil in the blood peaks after 60 minutes of taking the medicine. Thus, making the effects strongest around this time.
As mentioned, Sildenafil is also used to treat Pulmonary Arterial Hypertension (PAH).
For PAH treatment, you need to take Sildenafil doses three times a day.
The effects of Sildenafil begin to diminish as time passes between doses. This is why taking the medication three times after every 4-6 hours is necessary.
This dosing schedule ensures that there is a consistent level of the medication in the body. Thus, continuously improving blood flow in the pulmonary arteries.
Factors affecting the duration of effects of Sildenafil
Several factors can affect the duration of the effects of Sildenafil.
These include age, health conditions, diet, psychological state, etc.
Here we discuss all of these in detail.
Older individuals may experience a longer duration of action due to slower metabolism.
But this can also increase the risk of side effects and interactions.
Thus, starting with a lower dose of Sildenafil and monitoring the response is advisable.
Underlying health conditions can also impact the longevity of the effects of Sildenafil.
These conditions include Diabetes, Atherosclerosis, and Multiple Sclerosis (MS). These all can make Sildenafil less effective and not last for long.
In contrast, some health conditions like liver disease can slow your metabolism.
This allows Sildenafil to show a longer-lasting effect. But, this can increase the risk of side effects and drug interactions.
If you take Sildenafil with a heavy meal, it can delay its absorption into the bloodstream.
This delay elongates the metabolization time of the medicine. Thus, leading to delayed response and long-lasting effects.
Although it extends the duration of effects, it reduces the total efficacy of Sildenafil.
As per a study, it reduced the highest concentration of Sildenafil in the bloodstream by 29%.
So, it is advisable to consume Sildenafil on an empty stomach or with a lighter meal.
Psychological factors like anxiety, etc., can also affect the effectiveness of Sildenafil.
If a person is not relaxed or comfortable, the medication may not be as long-lasting or effective.
How long does Sildenafil take to eliminate from the body
Sildenafil starts leaving your system within 4-5 hours. But it may take approximately 24 hours to eliminate from the body fully.
It is dependent on your metabolism and the dosage taken.
After you take the medicine, your liver metabolizes it. Suppose you have a slow metabolism due to any factor.
In that case, Sildenafil will take longer to leave your system and vice-versa.
On the other side, higher doses take longer to get eliminated from the body than lower doses. For example, a 25mg dose of Sildenafil wears off four times more quickly than a 100mg dose.
What happens when Sildenafil lasts too long?
Although Sildenafil is a safe treatment, it can cause adverse effects.
If it lasts too long in the body, it can cause complications like Priapism and chest pain.
Prolonged erections (Priapism) can cause pain and long-term damage to the penis.
This is why doctors prescribe Sildenafil to people without issues related to metabolization and excretion of the medicine.
If you experience these issues, seek medical attention immediately.
In summary, Sildenafil lasts for up to 4 hours in the body. It may also show effects past this point.
The duration of effects of Sildenafil varies depending on several factors. These include age, health conditions, diet, etc.
It is an effective and safe treatment, but not for everyone.
People with kidney or liver diseases should avoid taking Sildenafil. This is because it stays for longer in their bodies and causes complications.
Thus, it is advisable to contact a doctor before taking any medicine. Also, inform the doctor about your medical history.
This helps him/her to determine whether Sildenafil is safe for you or not.
Frequently Asked Questions
How long does Sildenafil last in the body?
Sildenafil can last up to 4 hours in the body. But this duration varies from person to person, depending on the individual’s health and medical conditions.
Can the effects of Sildenafil last longer than 4 hours?
Yes, in some cases, the effects of Sildenafil may last longer than 4 hours. As per one study, Sildenafil’s effects lasted for 12 hours in men with ED. But, these effects got weaker over time.
What factors can affect the duration of Sildenafil’s effects?
Several factors can affect the duration of Sildenafil’s effects. These include age, health conditions, psychological state, and diet.
When is the best time to take Sildenafil to ensure its maximum effectiveness?
The best time to take Sildenafil is 1 hour before sexual activity. This is because Sildenafil reaches its peak concentration after 60 minutes of ingestion. Around this point, its effects on the body are the strongest.
How often should I take Sildenafil for Pulmonary Arterial Hypertension treatment?
For treating Pulmonary Arterial Hypertension (PAH), you need to take it three times a day. This is because Sildenafil remains effective for only 4-5 hours in the body. So, taking three Sildenafil doses after every 4-6 hours is necessary. This ensures a consistent level of the medication in the body.
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