How Long Do the Effects of Tadalafil Last

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Written By Julie Ingram
How Long Do the Effects of Tadalafil Last

Tadalafil is a popular medication used to treat Erectile Dysfunction (ED), Benign Prostatic Hyperplasia (BPH), and Pulmonary Arterial Hypertension (PAH).

Erectile Dysfunction is the inability of men or Assigned Males at Birth (AMAB) to get and maintain a firm erection. 

BPH is a condition involving the enlargement of the prostate gland, whereas PAH is characterized by high blood pressure in the lung’s arteries. 

Tadalafil is marketed and sold under two brand names, i.e., “Cialis” for ED, BPH, and “Adcirca” for PAH. 

One of the key advantages of Tadalafil is its long-lasting effects. This makes it a preferred choice for many individuals seeking an ED, BPH, or PAH solution. 

This article will explore how long do the effects of Tadalafil last, the benefits of its extended effectiveness, and discuss factors that may influence its duration. 

How long do the Tadalafil’s effects last

The effects of Tadalafil last for up to 36 hours after ingestion. 

Due to its longer-lasting effects, Tadalafil has earned the nickname “The Weekend Pill“. 

Among all the Erectile Dysfunction pills, the effects of Tadalafil last for longer. 

Thus, allowing for greater spontaneity in sexual activities, as it does not require precise timing before intimacy.

However, it does not imply that you will experience erection continuously for 36 hours. Instead, Cialis allows you to achieve multiple erections if sexual stimulation is present during this timeframe. 

Additionally, studies have shown that Cialis reduces the time it takes to get another erection after ejaculation, which is known as the refractory period. 

This can lead to more fulfilling and satisfying sexual experiences.

Moreover, Tadalafil’s long-lasting effects and “once-daily” dosing make it suitable for BPH and PAH. This is because these conditions require continuous medication in the body to manage their associated symptoms effectively.

It is important to understand that the duration of effects of Tadalafil may vary from person to person, depending on individualistic factors. 

One research has shown that Tadalafil remained effective for up to 72 hours in some men. 

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  • Factors affecting the duration of action of Tadalafil

    Several factors such as metabolism and medicine interactions influence how long the effects of Tadalafil last in an individual.

    1. Individual Metabolism

    Each person’s metabolism can affect how quickly the medication is absorbed and processed by the body.

    This can influence the duration of Tadalafil’s effects. 

    2. Medical Interactions

    Certain medications like Nitrates and Alpha-blockers can interact with Cialis.

    This can affect its metabolism and effectiveness. Thus, reducing Tadalafil’s effects or leading to adverse reactions. 

    3. Tolerance

    Due to the long-term use of the medication, the body becomes less responsive to it over time. This is known as the development of tolerance. 

    It can affect how long the effects of Tadalafil last. Thus, potentially requiring a higher dose to produce the desired effect. 

    Do not take more than one Tadalafil dose in 24 hours. If taken, it would be considered as overdosing on the medication.

    Benefits of long-lasting effects of Tadalafil

    The benefits of long-lasting effects of Tadalafil include enhanced spontaneity, increased sexual confidence, daily use for BPH, PAH, and reduced refractory period. 

    Hypertensive patientSource: Dimic_from_Getty_Images_Signature
    Checking blood pressure (Hypertensive patient)

    1. Enhanced Spontaneity

    Tadalafil’s remarkable duration of action, lasting up to 36 hours, allows users to engage in sexual activities spontaneously. 

    Unlike some other ED medications that require precise timing, it allows for greater flexibility without planning in advance.

    2. Increased Sexual Confidence

    Dealing with ED can often lead to feelings of anxiety and performance pressure. 

    Tadalafil’s long-lasting effects can help boost sexual confidence by reducing worries related to erection.

    3. Reduced Refractory Period

    Studies have shown that Tadalafil may reduce the refractory time. 

    This can lead to more frequent sexual activity and increased sexual satisfaction for both partners.

    4. Daily Use for BPH and PAH

    Tadalafil’s extended duration and “once-daily” dosing option ensure that continuous medication is present in the body. 

    Thus, making it an excellent choice for managing Benign Prostatic Hyperplasia and Pulmonary Arterial Hypertension. 

    A lower dose of Tadalafil can be taken daily for Erectile Dysfunction, too, if your doctor prescribes it. This helps to mitigate the risk of progression of the disease.


    The effects of Tadalafil last up to 36 hours. Thus, offering an array of benefits for men seeking effective treatment for Erectile Dysfunction, Benign Prostatic Hyperplasia, and Pulmonary Arterial Hypertension. 

    Its long-lasting action increases spontaneity, boosts sexual confidence, and improves overall relationship satisfaction. 

    However, individual factors like metabolism, tolerance to the medication, and medical conditions can influence the duration of Tadalafil’s effects. 

    It is advisable to consult a doctor to ensure a safe and personalized experience. 

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    Frequently Asked Questions

    Can Tadalafil cause Priapism?

    Although rare, priapism (a prolonged erection lasting more than four hours) is a potential side effect of Tadalafil. Seek medical attention immediately if this occurs.

    Can Tadalafil be used for recreational purposes?

    No, Tadalafil is a prescription medication intended for the treatment of Erectile Dysfunction, PAH, and BPH. Using it recreationally is not recommended and may lead to adverse effects.

    How often can I take Tadalafil?

    Tadalafil should not be taken more than once every 24 hours. Stick to your doctor’s prescribed dosing schedule for the best results.

    How long does Tadalafil take to start working?

    Tadalafil takes 30 minutes to start working. This is because the medication takes time to absorb and metabolize in the body after ingestion. Therefore, it is recommended to take Tadalafil approximately 30 minutes before sexual activity and enjoy the effects for 36 hours.

    Can Tadalafil be used daily for ED treatment?

    Yes, Tadalafil can be taken daily at lower doses for continuous effectiveness in managing Erectile Dysfunction (ED). It allows spontaneous sexual activity without the need for timing restrictions.

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