Understanding the Impact of Tadalafil on Blood Pressure 

Published On
Written By Julie Ingram
impact of tadalafil on blood pressure

Tadalafil is one of the most popular medications for Erectile Dysfunction (ED). 

ED is the inability of men or Assigned Males at Birth (AMAB) to get and maintain a firm erection. 

Tadalafil is also approved for treating conditions beyond ED, i.e., Benign Prostatic Hyperplasia (BPH) and Pulmonary Arterial Hypertension (PAH). 

This medication has undergone rigorous testing and verification. Thus, it is effective, safe, and has good tolerance but can impact blood pressure.

Understanding the relationship between Tadalafil and its effect on blood pressure is essential for safely using this medication. This helps individuals to take necessary measures in case of any adverse outcomes.

This article will explore the impact of Tadalafil on blood pressure, the risks associated with this effect, and discuss the safety considerations. 

Impact of Tadalafil on blood pressure

Tadalafil is a medication that lowers blood pressure due to its vasodilatory properties. This means it opens the blood vessels to improve blood flow, which impacts blood pressure. 

This medication is mainly used to treat Erectile Dysfunction (ED). 

It belongs to a class of Phosphodiesterase Type 5 (PDE5) inhibitors, which works by inhibiting the PDE5 enzyme. 

By doing so, Tadalafil increases cyclic Guanosine Monophosphate (cGMP) levels that relax the smooth muscles in blood vessels. 

This relaxation leads to the dilation of blood vessels and increases blood flow to the erectile tissues.

Thus, helping men or AMAB to get and maintain a firm erection during sexual stimulation.

However, the impact of Tadalafil is not limited to the penile region alone. Its effects extend to other body parts, due to which it dilates blood vessels throughout the body.

This vasodilation (widening of blood vessels) in the body may slightly lower blood pressure. 

The lowering of blood pressure is generally mild and well-tolerated by most individuals. It is not a matter of concern in healthy men. 

But this can cause risks in individuals with pre-existing low blood pressure symptoms or when Tadalafil is used in combination with other blood-lowering medications. 

Quick Checkout:
Get long-lasting sexual pleasure with Tadalafil- Shop generic versions at Fordaily Medicine:

  • Tadarise 5 mg
  • Tadarise 60 mg
  • Risks associated with Tadalafil’s impact on blood pressure

    Heart problemSource: Thatphichai Yodsri_from_Getty_Images
    Heart disease

    Various risks arise due to the impact of Tadalafil on blood pressure. 

    These include the risk of Hypotension, interaction with Nitrates, and cardiovascular risks. 

    1. Hypotension

    One of the significant risks associated with the impact of Tadalafil on blood pressure is Hypotension, which refers to abnormally low blood pressure. 

    Most individuals experience a mild decrease in blood pressure after using Tadalafil. But some people may be more vulnerable to a dangerous drop. 

    This risk is concerning when Tadalafil is used in combination with other blood-pressure-lowering medications or in individuals who already have symptoms of low blood pressure.

    2. Interaction with Nitrates 

    The interaction of Tadalafil with Nitrates is a critical concern. 

    Nitrates are prescribed for treating Angina (chest pain). Similar to Tadalafil, they also exert blood-lowering effects. 

    A dangerous drop in blood pressure can happen if both medicines are taken alongside. This may result in severe health issues or life-threatening complications. 

    Thus, Tadalafil should never be used in combination with Nitrates.

    3. Cardiovascular Risks

    Individuals with underlying cardiovascular conditions, like heart disease or recent heart attacks, must be cautious when using Tadalafil. 

    Although the impact of Tadalafil on blood pressure is generally well-tolerated, individuals with impaired cardiovascular systems may be more vulnerable to this impact.  

    Understand all the drug and disease interactions before starting Tadalafil’s treatment. This can help prevent the major consequences. 

    Safety considerations

    To reduce the risk of Tadalafil’s effect on blood pressure, certain safety considerations must be adhered to. 

    These include consulting a doctor, avoiding Nitrates, and regularly monitoring blood pressure. 

    1. Medical Consultation

    man with low blood pressureSource: Milos Dimic from Getty Images Signature
    Checking blood pressure (consult doctor before taking medicine)

    Before starting Tadalafil treatment, individuals should consult their doctor. 

    A thorough medical evaluation, including a review of cardiovascular health and blood pressure levels, is crucial to identify any potential risks.

    2. Avoid Nitrates

    As mentioned earlier, the simultaneous use of Tadalafil and Nitrates is strictly contraindicated. 

    Individuals taking Nitrates should avoid this medication and inform their doctor about this during consultation. 

    3. Blood Pressure Monitoring

    Regular monitoring of blood pressure is essential during Tadalafil treatment, especially for individuals with hypotensive symptoms or cardiovascular conditions. 

    This ensures that blood pressure remains within safe limits and allows for timely adjustments if necessary.

    If you are taking Hypertension medication and considering using Tadalafil, it is crucial to consult your doctor. This is because there may be a possibility of drug-drug interaction.


    The impact of Tadalafil on blood pressure is due to its vasodilatory properties. 

    Although this effect is generally mild, individuals should be aware of potential risks. 

    People using Tadalafil alongside other medications like Nitrates or having certain medical conditions like Hypotension should be extra careful while using this medication.  

    Responsible usage of Tadalafil involves seeking medical advice, being transparent about one’s medical history, and adhering to safety precautions to ensure its safe and effective use.

    Checkout Cart:
    Free yourself from the shackles of Erectile Dysfunction- Shop Tadalafil today!

    Frequently Asked Questions

    Can Tadalafil interact with blood pressure medications? 

    Yes, Tadalafil can interact with certain blood pressure medications, particularly those containing Nitrates. 
    Combining Tadalafil with Nitrates can cause a severe drop in blood pressure, which can be dangerous. Always inform your doctor about all medications you are taking to avoid potential interactions.

    Will Tadalafil raise my blood pressure if it is already low? 

    Tadalafil can cause a drop in blood pressure, but it is less likely to raise blood pressure if it is already low. 
    However, if you have concerns about your blood pressure, discuss them with your doctor before using this medication. 

    How often should I monitor my blood pressure while using Tadalafil? 

    If you are using Tadalafil, your doctor may recommend regular blood pressure monitoring. 
    The frequency of monitoring will depend on your specific health condition and how your body responds to the medication.

    Is it safe to use Tadalafil if I am on blood pressure-lowering medications? 

    If you are taking blood pressure-lowering medications, consult your doctor before using Tadalafil. 
    Your doctor will assess the potential interactions and determine if this medication is safe to use alongside your current medications.

    When quoting information, ForDailyMedicine always provides full citations. Please read our Content Information Policy if you want more details on the methods we take to ensure the continued high quality of our content.