Is it Safe Taking Tadalafil with Other Medications

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Written By Julie Ingram
Tadalafil with other medications

Tadalafil is a medicine used to treat Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH). 

It is commonly known by its brand name Cialis, which belongs to the group of Phosphodiesterase Type 5 (PDE5) inhibitors. 

Since patients take this medicine for various health conditions, it becomes essential to understand the safety of taking Tadalafil with other medications.

This article examines the safety considerations and possible interactions of Tadalafil with other medicines. 

Informed medical guidance for individuals aims to maximize the advantages of this medication while ensuring their general health. 

Can you take Tadalafil with other medications

Yes, Tadalafil can be taken safely with certain medications.  

Some Cialis combinations with other medicines are considered safe to use, which include

  1. Common Pain Relievers: Over-the-counter pain relievers like Acetaminophen and Ibuprofen are safe to take with Cialis.
  2. Antihistamines: Medications used to treat allergies, like Zyrtec, are usually compatible with Tadalafil.
  3. Selective Alpha-Blockers: Some newer alpha-blockers, like Silodosin, is safe to use with Tadalafil. 

However, it is crucial to be cautious with Tadalafil, as it can interact with some medicines. Thus, leading to potential side effects like low blood pressure. 

Let’s delve deeper into the medicines that must be avoided while taking Tadalafil. 

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  • Medicines to avoid while taking Tadalafil

    If you’re taking Tadalafil, it is important to avoid certain medications to prevent drug interactions.

    The list of medicines that can intensify the risk of side effects when taken together with Tadalafil include:


    Nitrates are commonly used to treat Angina (chest pain).

    If you’re taking Tadalafil to treat ED or BPH, do not take Nitrates or Nitrates containing medicines.

    This is because both medications cause a significant decrease in blood pressure. 

    Taking these medicines together can intensify the blood-lowering effect and lead to the condition known as Hypotension.

    Hypotension is characterized by extremely low blood pressure, whose symptoms include dizziness, fainting, and even a heart attack.

    Hypertensive patient performing an automatic blood pressure test 
Source: Milos Dimic from Getty Images Signature
    Hypertensive patient performing an automatic blood pressure test

    Certain Alpha-Blockers

    Alpha-blockers are used to treat high blood pressure and Benign Prostatic Hyperplasia (BPH).

    When combined with Tadalafil, both drugs can cause a dangerous drop in blood pressure. 

    Thus, leading to symptoms like dizziness or fainting.

    Therefore, if you are using an Alpha-blocker like Doxazosin, avoid taking Tadalafil. 

    Certain Alpha-blockers like Tamsulosin, when taken with Tadalafil, do not intensify the blood pressure-lowering effect. 

    Protease inhibitors

    Tadalafil (sold under the brand name Cialis) can interact with Protease Inhibitors, which are medications used to treat HIV.

    Protease inhibitors slow down how quickly your liver processes the medication. This can increase the levels of Tadalafil in the blood.

    Thus, increasing the risk of side effects like headache, flushing, indigestion, and prolonged erections (Priapism).

    If you are taking Protease inhibitors, your doctor may adjust the dose of Tadalafil or recommend an alternative ED treatment.

    Antibiotics and Antifungals

    Antibiotics (e.g., Erythromycin) and Antifungals (e.g., ketoconazole) can interfere with Tadalafil’s metabolism and affects its clearance from the body. 

    This increases the level of the medication in the blood. Thus, increasing the risk of Tadalafil side effects. 

    In this case, your doctor may adjust the dosage or recommend a different treatment.

    Always inform your doctor if you’re taking any prescription or over-the-counter medicines before starting Tadalafil treatment. This helps the doctor determine whether this medication is safe for you or not.

    Other Erectile Dysfunction pills

    Combining ED pills like Sildenafil with Tadalafil is risky due to potential interactions. 

    This can cause issues ranging from headaches to dangerous drops in blood pressure and heart-related concerns. 

    The lack of comprehensive data on mixing these drugs raises more concerns. 

    Therefore, consult a doctor before considering such combinations to stay safe and achieve effective treatment.


    The safe use of Tadalafil with other medicines requires careful consideration and consultation with a doctor. 

    It can be used alongside certain drugs, like Ibuprofen, Zyrtec, Silodosin, etc. 

    However, Tadalafil can interact with Nitrates, Alpha-blockers, Protease inhibitors, Antibiotics, and other ED pills. 

    These combinations can lead to adverse effects, including severe drops in blood pressure and increased side effects. 

    To ensure your well-being and treatment success, it is important to inform your doctor about all medications and supplements you are taking.

    This can help them assess if Tadalafil is safe and effective for you or not. 

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    Frequently Asked Questions

    For how long does the effect of the interaction of Tadalafil and Nitrates last?

    As per a study, the effects of interaction between Tadalafil and Nitrates last for 24 hours.

    Can Tadalafil interact with herbal supplements or vitamins?

    Tadalafil can potentially interact with herbal supplements and vitamins, especially those affecting blood pressure or metabolism.

    Supplements like Ginseng, Ginkgo Biloba, Yohimbe, etc., might impact Tadalafil’s effects and increase the risk of side effects.

    How much should I wait to use Nitrates after taking Tadalafil?

    Tadalafil and Nitrates should not be combined as it can lead to a dangerous drop in blood pressure. 

    If necessary, wait for a minimum of 48 hours (2 days) after taking Tadalafil before using Nitrates.

    Is alcohol consumption safe while taking Tadalafil with other medications?

    Alcohol can exacerbate the side effects of Tadalafil’s interactions. These effects include dizziness and low blood pressure. 

    Thus, it is advisable to limit alcohol consumption while using Tadalafil with other medicines.

    What should I do if I experience side effects while taking Tadalafil with other medications?

    If you experience any adverse effects or unusual symptoms, seek medical attention immediately. 

    Inform your doctor about all the medications you are taking to help them determine the safety of Tadalafil.

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