Generic Name: Depoxetine
Brand Name: Priligy

Depoxetine structure

What is Dapoxetine

Dapoxetine is a drug primarily prescribed for treating Premature Ejaculation (PE) in men. 

The medicines containing this salt help increase the time taken to ejaculate and have better control over ejaculations during sexual intercourse. 

Uses of Dapoxetine

Dapoxetine is an FDA-approved drug used as an effective treatment to treat Premature Ejaculation. 

It is a disorder when a man orgasms (ejaculates) more quickly than he and/or his partner would like. 

For some men, it can be temporary and get better on its own; for others, prescribed treatments such as Dapoxetine tablets can be helpful.

PE can be caused due to several emotional and physical factors. 

How does Dapoxetine work

Dapoxetine is part of the group of Selective Serotonin Reuptake Inhibitors (SSRI). 

Serotonin in the human body works as a neurotransmitter and is primarily responsible for ejaculation. It is prompted by serotonin uptake by cells during intercourse. 

The mechanism of action of SSRIs involves blocking Serotonin reuptake by cells. As a result, the effects of Serotonin-induced signals are extended.

Chronic usage of SSRI antidepressants has been proven to prolong the time between erection and ejaculation in men.

Dapoxetine Dosage

It is usually recommended to take single Dapoxetine-containing pills at least 1 to 3 hours before the sexual activity. 

One can take medicine containing this salt with or without food. Your doctor might recommend different strengths of Dapoxetine according to your age and disease severity. 

Never take more than one tablet containing the salt to treat PE within 24 hours; it might lead to an overdose of the medicine.  

Dapoxetine is commonly available in combination with Sildenafil Citrate, Vardenafil, and Tadalafil

The combination pills are recommended as a treatment for Erectile Dysfunction and Premature Ejaculation. 

Who can take Dapoxetine

Dapoxetine is prescribed for men between the ages of 18 to 60. It is usually prescribed for men suffering from PE for six months or more. 

The salt is not recommended for use by women and children. 

Men with heart diseases and who have blood clotting issues should inform the doctor about their medical history before consuming the medicine. 

Dapoxetine Side Effects

Dapoxetine is a safe drug for the treatment of PE in men but might cause mild side effects, which include,

  • Headaches 
  • Dizziness
  • Diarrhea
  • Nausea and Vomiting

How to manage Dapoxetine side effects

The side effects of tablets containing Dapoxetine are mild. They go away themselves after some time or require painless treatments. 

  • Feeling dizzy or light-headed: Sit with your head between your knees, or lie down until the feeling passes
  • Nausea or Vomiting: You can take Vomistop for easy relief 
  • Headache: Drink plenty of water and rest 

Dapoxetine Interactions

Dapoxetine might interact with certain medications and diseases to show side effects. Hence, inform your physician before taking medicine. 

Drug interactions

The salt for Premature Ejaculation treatment interacts with certain drugs. If you take the following medications, please inform your doctor about the same, 

  • Antibiotics
  • Antifungal medicines
  • Ketoconazole
  • Medicines for Bipolar disorders (Lithium)
  • Tramadol
  • Warfarin
  • Ritonavir
  • Verapamil 

Disease interactions


Glaucoma is an eye disorder caused due to increase in the fluid pressure inside the eyeballs. If not treated, it can lead to blurred vision or blindness. The salt should be avoided or used carefully if you have Glaucoma due to the increased risk of side effects and worsening of your condition.

Renal Dysfunction

Dapoxetine should be used carefully if you have mild to moderate kidney problems. Renal dysfunction may lead to the accumulation of this medicine in the body and lead to side effects. 


  • One should avoid taking Dapoxetine-containing tablets if they are allergic to Dapoxetine
  • Heart patients should consult their physician before taking the medicine
  • If you are taking other SSRI drugs, it might lead to an overdose. 
  • Tablets containing the salt to treat PE are not safe to be used in women and children. 

Pros and Cons of Depoxetine

Pros Cons
It is a safe drug to treat PE. Medicine containing salt to treat PE is not safe for people who have had a stroke or a heart attack within the past six months. 
It is a stable salt that can work in combination with PDE5 inhibitors to treat ED.It can cause side effects in people who do not follow the doctor’s prescription. 
It starts to act just after 30 minutes to 1 hour of intake.
Dapoxetine’s efficacy can be maintained with occasional use; there’s no need to take it regularly.


Keep the medicine away from sunlight and moisture and at room temperature between 18 to 30 degrees Celsius.

Other Products with Similar Salts

Frequently Asked Questions

How long does Dapoxetine make you last?

Dapoxetine is most effective for 1 to 3 hours of intake. After a few weeks of medication, men can observe a doubling and tripling time before ejaculation.

Can I use Dapoxetine daily?

Dapoxetine oral pills can be consumed once daily or as prescribed by your doctor during therapy. Within a 24hours period, no more than one tablet may be used for daily treatment.

Can I take Dapoxetine with Viagra?

There are no interactions observed when Dapoxetine and Viagra are taken together. However, you should consult your doctor before taking the two medicines together.

Who should not take Dapoxetine?

Men under 18 or older than 65 should not use Dapoxetine. It is not safe to use on women and children. People who have suffered a heart attack or have liver disorders should avoid taking medicine.

When is the best time to take Dapoxetine?

A single tablet should be taken when needed, about 1 to 3 hours before sexual activity. Do not take more than one tablet in 24 hours.

Does Dapoxetine increase blood pressure?

No, Dapoxetine belongs to a group of Selective Serotonin Reductase Inhibitors. The SSRI drugs do not affect blood pressure levels.

Does Dapoxetine permanently cure PE?

No, PE is a controllable disorder. It cannot be cured permanently. Dapoxetine is a trusted medication to control PE.

What happens after taking Dapoxetine?

Dapoxetine is prescribed for the treatment of Premature Ejaculation. Take one tablet 1-3 hours before you have sex. The salt acts to reduce serotonin uptake by the cells.

The reduced serotonin amount leads to an increase in time before ejaculation.

What is the side effect of Dapoxetine?

Dapoxetine is a safe treatment for Premature Ejaculation but might have mild side effects if not taken carefully. The side effects include dizziness, diarrhea, vomiting, and headache.

Is Dapoxetine safe to take?

Yes, Dapoxetine is a safe and effective salt to treat Premature Ejaculation in men.